With the development of liver disease, liver cell necrosis, diffuse nodular regeneration of liver parenchyma and deposition of collagen fibers which ultimately caused the liver structural changes, eventually lead to cirrhosis. 随着肝脏病变的发展,肝细胞坏死,肝实质弥漫性结节再生,胶原纤维大量沉积,最终导致肝组织结构改变,发展为不可逆转的肝硬化。